Medication adherence and quality of life in patientes with multidrug-resistant tuberculosis
DOI:
https://doi.org/10.17058/reci.v16i.19888Keywords:
Multidrug-Resistant Tuberculosis, Medication Adherence, Quality of LifeAbstract
Background and Objectives: The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) is associated with challenges in treatment adherence and impacts on quality of life (QoL). This study aimed to evaluate medication adherence and QoL in patients with MDR-TB. Methods: A cross-sectional, descriptive, and quantitative study was conducted in Northeastern Brazil, following the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) statement. In total, 50 patients participated in interviews using a semi-structured instrument. Adherence was assessed using the Brief Medication Questionnaire (BMQ). QoL was measured using the World Health Organization Quality of Life (WHOQOL-BREF). Results: Most participants were male (56%), 18–45 years old (60%), Black (86%), single (58%), with an income ≤1 minimum wage (98%), and incomplete high school (68%). According to the BMQ, 80% were adherent to treatment; 80% showed potential adherence to the regimen; 82% tested negative for belief barriers; and 92% tested negative for recall barriers. According to the WHOQOL-BREF, 50% considered their QoL to be fair. When considering the results by domain, the average scores ranged from 1.63 to 3.59. The social relationships domain had the lowest average (1.63±0.662), while the psychological domain had the highest average (3.59±0.958). Conclusion: High therapeutic adherence was demonstrated according to the BMQ criteria, contrasting with disparities in QoL, especially in the social relationships domain. The data reinforce the need for targeted psychosocial interventions to mitigate the identified gaps and ensure treatment Sustainability
Downloads
References
1. Santos TA, Martins MMF. Perfil dos casos de reingresso após abandono do tratamento da tuberculose em Salvador, Bahia, Brasil. Cad Saude Colet. 2018; 26(3):233-240. doi: 10.1590/1414-462X201800030235
2. Rodriguez-Morales AJ, Abara A, Ntoumi F, et al. World Tuberculosis Day 2023 – Reflections on the spread of drug-resistant tuberculosis by travellers and reducing risk in forcibly displaced populations. Travel Med Infect Dis. 2023; 53:102568. doi: 10.1016/j.tmaid.2023.102568
3. Ballestero JGA, Garcia JM, Bollela VR, et al. Management of multidrug-resistant tuberculosis: main recommendations of the Brazilian guidelines. J Bras Pneumol. 2020; 46(2):e20190290. doi: 10.36416/1806-3756/e20190290
4. Akalu TY, Clements ACA, Wolde HF et al. Prevalence of long-term physical sequelae among patients treated with multi-drug and extensively drug-resistant tuberculosis: a systematic review and meta-analysis. eClinicalMedicine. 2023; 57:101900. doi: 10.1016/j.eclinm.2023.101900
5. Ferreira DP, Souza FA, Motta MCS. Prevalência da coinfecção HIV/TB em pacientes de um hospital de referência na cidade do Rio de Janeiro. Rev Fund Care Online. 2019; 11(2):358-362. doi: 10.9789/2175-5361.2019.v11i2.358-362
6. World Health Organization. Global Tuberculosis Report 2021 [Internet]. Geneva: World Health Organization; 2021. Disponível em: https://www.who.int/publications/i/item/9789240037021
7. Oliveira LGF, et al. Incidência da tuberculose na Bahia: o retrato de uma década. RevISE [Internet] 2020; 4(0):79-88. Disponível em: https://www3.ufrb.edu.br/index.php/revise/article/view/1856/1022
8. Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986;24(1):67-74. doi: 10.1097/00005650-198601000-00007
9. Fleck MPA, Fachel O, Louzada S, et al. Desenvolvimento da versão em português do instrumento de avaliação de qualidade de vida da Organização Mundial da Saúde (WHOQOL-100). Rev Bras Psiquiatr. 1999; 21:19-28. doi: 10.1590/S1516-44461999000100006
10. Fregona G, Cosme LB, Moreira CMM, et al. Risk factors associated with multidrug-resistant tuberculosis in Espírito Santo, Brazil. Rev Saúde Pública. 2017; 51. doi: 10.1590/S1518-8787.2017051006688
11. Lima CM, Arruda HAA, Rocha RPS, et al. Desafios de enfermeiras frente à saúde do homem na atenção básica. Res Soc Dev. 2021; 10(1). doi: 10.33448/rsd-v10i1.11885
12. Yang BR, Kang YA, Heo EY, et al. Regional differences in the incidence of tuberculosis among patients with newly diagnosed diabetes mellitus. Clin Respir J. 2018; 12(4):1732-1738. doi: 10.1111/crj.12737
13. Silva TC, Pinto ML, Orlandi GM, et al. Tuberculosis from the perspective of men and women. Rev Esc Enferm USP. 2022; 56. doi: 10.1590/1980-220X-REEUSP-2022-0137pt
14. Martins JP, Machado RC, Conceição ADA, et al. Epidemiological Profile of Tuberculosis Cases Related to Treatment Abandonment in Maranhão from 2017 to 2020. Braz J Dev [Internet]. 2021; 7(6):59-102. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/31394
15. Arroyo LH, Yamamura M, Ramos A, et al. Determinants of multidrug-resistant tuberculosis in São Paulo-Brazil: a multilevel Bayesian analysis of factors associated with individual, community and access to health services. Trop Med Int Health. 2020; 25(7):839-849. doi: 10.1111/tmi.13409
16. Tan ZM, Lai GP, Pandey M, et al. Novel Approaches for the Treatment of Pulmonary Tuberculosis. Pharmaceutics. 2020; 10;12(12):1196. doi: 10.3390/pharmaceutics12121196
17. Denominato PM. O Nitroredutases como alvo terapêutico na tuberculose [dissertação]. Lisboa: Universidade de Lisboa; 2022.
18. Ategyeka PM, Muhoozi M, Naturinda R, et al. Prevalence and factors associated with reported adverse-events among patients on multi-drug-resistant tuberculosis treatment in two referral hospitals in Uganda. BMC Infect Dis. 2023; 23(1):149. doi: 10.1186/s12879-023-08085-3
19. Freitas GL, França GEM, Souza TR, et al. Diagnóstico e acompanhamento da tuberculose – diferenças entre população geral e populações vulnerabilizadas. Cogitare Enferm. 2022; 27(0):e83607. doi: 10.5380/ce.v27i0.83607
20. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico: Tuberculose 2022 [Internet]. Brasília: Ministério da Saúde; 2022. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/epidemiologicos/especiais/2022/boletim-epidemiologico-de-tuberculose-numero-especial-marco-2022.pdf
21. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Manual de Recomendações para o Controle da Tuberculose no Brasil [Internet]. Brasília: Ministério da Saúde; 2021. Disponível em: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/tuberculose/manual-de-recomendacoes-e-controle-da-tuberculose-no-brasil-2a-ed.pdf/view
22. Teixeira LM, Palmeira IP, Matos WDV, et al. Concepções sobre tratamento e diagnóstico da tuberculose pulmonar para quem a vivencia. Esc Anna Nery. 2023; 27. doi: 10.1590/2177-9465-EAN-2022-0156pt
23. Büsselmann M, Nigel S, Otte S, et al. High Quality of Life Reduces Depression, Hopelessness, and Suicide Ideations in Patients in Forensic Psychiatry. Front Psychiatry. 2020; 10:1014. doi: 10.3389/fpsyt.2019.01014
24. Ferreira MCAS, Fernandes RAQ. Mulheres detentas do Recife-PE: saúde e qualidade de vida. Esc Anna Nery. 2020; 24(4). doi: 10.1590/2177-9465-EAN-2020-0062
25. Tornu E, Quarcoopome L. Correlates of quality of life among persons living with tuberculosis: A cross-sectional study. PLoS One. 2022; 17(11):e0277192. doi: 10.1371/journal.pone.0277192
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Tacyla Rayssa Carneiro Amorim, Débhora Ísis Barbosa e Silva, Tainara Barbosa Nunes, Conceição Maria de Oliveira, Maria Mariana Barros Melo da Silveira, Amanda Tavares Xavier, Fábio Henrique Portella Corrêa de Oliveira, Keylla Talitha Fernandes Barbosa, João Victor Batista Cabral
This work is licensed under a Creative Commons Attribution 4.0 International License.
The author must state that the paper is original (has not been published previously), not infringing any copyright or other ownership right involving third parties. Once the paper is submitted, the Journal reserves the right to make normative changes, such as spelling and grammar, in order to maintain the language standard, but respecting the author’s style. The published papers become ownership of RECI, considering that all the opinions expressed by the authors are their responsibility. Because we are an open access journal, we allow free use of articles in educational and scientific applications provided the source is cited under the Creative Commons CC-BY license.
