Prevalence of anti-Toxoplasma gondii antibodies in serum from donors from the blood center in Mato Grosso
DOI:
https://doi.org/10.17058/reci.v16i.20580Keywords:
Toxoplasmosis, Serology, Blood CenterAbstract
Background and Objectives: Toxoplasmosis is one of the most prevalent parasitic diseases in Brazil and occurs in healthy individuals with few or no symptoms. The aim of this study was to determine the prevalence of IgG and IgM antibodies to T. gondii in the serum of blood donors from Cuiabá, Mato Grosso. Methods: This was an observational cross-sectional study with 633 serum samples from blood donors at the Cuiabá Blood Center. A total of 633 serum samples from blood donors were obtained to investigate the prevalence of anti-T. gondii antibodies in Cuiabá, Mato Grosso. Results: The seroprevalence of T. gondii infection was 323/633 (51%). A total of 314/633 (49%) samples were seroreactive for IgG for T. gondii antibodies and nine (1.4%) samples with inconclusive results. In addition, 10/633 (1.57%) samples with IgM for T. gondii and 11 (0.1%) samples were inconclusive. Statistical analyses revealed significant differences for the presence of IgG for T. gondii in the stratifications by age, adults between 20-60 years of age, (p=0.000) and brown skin color (p=0.002). While for the presence of IgM for T. gondii, the variable geographic region of Cuiabá south (p=0.030) was also statistically significant. Conclusion: Based on the data obtained, it is inferred a relatively high prevalence of individuals with positive IgG antibodies for T. gondii in the blood samples of the tested donors, suggesting a chronic or past infection.
Downloads
References
1. Rahmanian V, Rahmanian K, Jahromi AS, Bokaie S. Seroprevalence of Toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses. J Family Med Prim Care. 2020;9(8):3848–55. DOI: 10.4103/jfmpc.jfmpc_753_20
2. Sengupta PP, Jacob SS, Suresh KP, Rajamani S, Maharana SM. Exploring global trends in human toxoplasmosis seroprevalence by meta-analysis. Experim Parasit. 2025;275:1-12. https://doi.org/10.1016/j.exppara.2025.108971
3. Margonato FB, Silva AMR, Soares DA, Amaral DA, Petris AJ. Toxoplasmose na gestação: diagnóstico, tratamento e importância de protocolo clínico. Rev. Bras. Saúde Mater. Infant. 2007;7(4):381-86. https://doi.org/10.1590/S1519-38292007000400005
4. Tenter AM, Heckerotha AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol. 2000; 30(12-13): 1217–58. DOI: 10.1016/s0020-7519(00)00124-7
5. Miller MJ, Aronson WJ, Remington JS. Late parasitemia in asymptomatic acquired toxoplasmosis. Ann. Intern. Med. 1969;71(1):139-45. DOI: 10.7326/0003-4819-71-1-139
6. Siegel SE, Lunde MN, Gelderman AH, Halterman RH, Brown JA, Levine AS, et al. Transmission of toxoplasmosis by leukocyte transfusion. Blood. 1971;37(4):388–94. https://doi.org/10.1182/blood.V37.4.388.388
7. Perkins HA, Busch MP. Transfusion-associated infections: 50 years of relentless chal lenges and remarkable progress. Transfusion. 2010;50(10):2080–99. DOI: 10.1111/j.1537-2995.2010.02851.x
8. Chiang TY, Hsieh HH, Kuo MC, Chiu KT, Lin WC, Fan CK, et al. Seroepidemiology of Toxoplasma gondii Infection among healthy blood donors in Taiwan. PLoSOne. 2012;7(10):1-7. https://doi.org/10.1371/journal.pone.0048139
9. Foroutan-Rad M, Majidiani H, Dalvand S, Daryani A, Kooti W, Saki J, et al. Toxoplasmosis in blood donors: A systematic review and meta-analysis. Transfus. Med. Rev. 2016;30(3):116-22. DOI: 10.1016/j.tmrv.2016.03.002
10. Kantzanou M, Kostares E, Kostare G, Papagiannopoulou E, Kostares M, Tsakris A. Prevalence of Toxoplasma gondii infection among blood donors: a systematic review and meta-analysis. Cureus. 2025 Jun 5;17(6):e85403. DOI: 10.7759/cureus.85403
11. Robert-Gangneux F, DardéML. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin. Microbiol. Rev. 2012;25(2):264–96. DOI: 10.1128/CMR.05013-11
12. Marin L, Miranda LS, Voigt MEF, Voigt MEF, Martire JPL, Nunes MRT, et al. Phylogeography of SARS-CoV-2 Omicron sublineages detected in asymptomatic blood donors during third epidemiological wave in Mato Grosso, Midwestern Brazil. Diagn. Microbiol. Infect. Dis. 2025;111(3):1-8. https://doi.org/10.1016/j.diagmicrobio.2025.116693
13. Dean AG, Sullivan KM, Soe MM OpenEpi: open source epidemiologic statistics for public health, Version 3. http://.www.OpenEpi.com/;2013
14. Instituto Brasileiro de Geografia e Estatística. População por idade e sexo. Censo 2022 [Internet]. Brasilia: 2022. Disponível em: https://biblioteca.ibge.gov.br/index.php/biblioteca-catalogo?view=detalhes&id=73102
15. Ministério da Saúde. Doação de sangue [Internet]. Brasilia: 2026. Acessado em 07 de abril de 2026. Disponível em: https://www.gov.br/saude/pt-br/composicao/saes/doacao-de-sangue
16. Prefeitura de Cuiabá. Perfil Socioeconômico de Cuiabá [Internet]. Cuiabá: 2009. Disponível em https://www.cuiaba.mt.gov.br/upload/arquivo/perfil_socioeconomico_de_cuiaba_Vol_IV.pdf
17. Lupu MA, Lighezan R, Paduraru AA, Dragomir A, Pavel R, Grada S, et al. Seroepidemiology of Toxoplasma gondii infection in blood donors from western Romania. Microorganisms. 2022;10(5):1-8. https://doi.org/10.3390/microorganisms10050973
18. Mahmoudvand H, Dezaki ES, Soleimani S, Baneshi MR, Kheirandish F, Ezatpour B, et al. Seroprevalence and risk factors of Toxoplasma gondii infection among healthy blood donors in south-east of Iran. Parasite Immunol. 2015;37(7):362–7. https://doi.org/10.1111/pim.12198
19. Nakashima F, Pardo VS, Miola MP, Murata FHM, Paduan N, Longo SM, et al. Serum IgG anti-Toxoplasma gondii antibody aoncentrations do not correlate nested PCR results in blood donos. Front. Cell. Infect. Microbiol 2020;9(461):1-6. https://doi.org/10.3389/fcimb.2019.00461
20. Assonia LCP, Nakashima F, Sousa VP, Paduan NJ, Andreasse IR, Anghinoni TH, et al. Seroepidemiology of Toxoplasma gondii infection in blood donors in a population from the northwestern region of São Paulo state, Brazil. Trans. R. Soc. Trop. Med. Hyg. 2024;118(2):102–9. DOI: 10.1093/trstmh/trad060
21. Paraboni MLR, Commodaro AG, Campi-Azevedo AC, Sousa JPB, Gonçalves IL , Costa DF, et al. Seroprevalence and systemic immune biomarkers associated with Toxoplasma gondii infection in blood donors from Southern Brazil. Immunol. 2022;227:1-8. https://doi.org/10.1016/j.imbio.2022.152294
22. Coêlho RAL, Kobayashi M, Carvalho LB. Prevalence of IgG antibodies specific to Toxoplasma gondii among blood donors in Recife, northeast Brazil. Rev. Inst. Med. Trop. Säo Paulo. 2003;45(4):229-31. https://doi.org/10.1590/S0036-46652003000400011
23. Vaz RS, Guimarães AT, Bonanato LD, Soccol VT. Technical evaluation of serological screening tests for anti–Toxoplasma gondii antibodicensoes to prevent unnecessary transfusion risks. Rev. Bras. Hematol. Hemoter. 2008;30(4):277–80. https://doi.org/10.1590/S1516-84842008000400009
24. Instituto Brasileiro de Geografia e Estatística. Conheça o Brasil cor ou raça [Internet]. Rio de Janeiro: 2022 [Cited 2025 Jun 06]. Available from: https://educa.ibge.gov.br/jovens/conheca-o-brasil/populacao/18319-cor-ou-raca.html
25. Galdino AKB, Bezerra MN, Macedo NLO, Sales SB, Moura HS. Perfil epidemiológico e prevalência de toxoplasmose no estado do Piauí entre 2019 e 2022. Rev. Contemp. 2024;4(5):1-17. https://doi.org/10.56083/RCV4N5-075
26. Lima Filho CA, Silva MVB, Santos JM, Trindade AMXB, Lima RYC, Silva FLT et al. Perfil epidemiológico da toxoplasmose adquirida na gestação e congênita no período de 2019 a 2021 na I região de saúde de Pernambuco. Rev. eletrônica acervo saúde. 2023; 23(5):1-10. https://doi.org/10.25248/reas.e11828.2023
27. Sousa MEG, Mar FM, Azevedo AP. Ocorrência da toxoplasmose no Amazonas: um olhar retrospectivo de cinco anos. RECIMA21- Rev. Cient. Multidiscip. 2024; 5(4):1-9. https://doi.org/10.47820/recima21.v5i4.5178
28. BRASIL. Ministério da Saúde. Coordenação geral de doenças transmissíveis. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/doencas-transmitidas-por-alimentos-dta/manual_dtha_2021_web.pdf
29. Saki J, Foroutan M, Khodkar I, Khodadadi A, Nazari L. Seroprevalence and molecular detection of Toxoplasma gondii in healthy blood donors in southwest Iran. Transfus. Apheresis Sci. 2019;58(1):79–2. 10.1016/j.transci.2018.12.003
30. Brasil. Ministério da Saúde. Portaria nº 158, de 4 de fevereiro de 2016. https://bvsms.saude.gov.br/bvs/saudelegis/gm/2016/prt0158_04_02_2016.html
31. Siegel SE, Lunde MN, Gelderman AH, Halterman RH, Brown JÁ, Levine AS, et al. Transmission of toxoplasmosis by leukocyte transfusion. Blood. 1971;37(4):388-94. https://doi.org/10.1182/blood.V37.4.388.388
32. Pinton DA. Reagent serology for Toxoplasma gondii in blood bags in the period of the Toxoplasmose outbreak in Santa Maria – RS. Rev. Bras. Anal. Clin 2022;54(3):262-66. DOI: 10.21877/2448-3877.202200947
33. Amorim, L. Toxoplasmose e transfusão de sangue. Rev. Bras. Hematol. Hemoter. 2008;30(4):259-65. https://doi.org/10.1590/S1516-84842008000400006
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Michelle Igarashi Watanabe, Vitória Marina Balbinot dos Anjos, Leonardo Marin, Eduarda Pavan, João Luis Garcia, Renata Dezengrini Slhessarenko

This work is licensed under a Creative Commons Attribution 4.0 International License.
The author must state that the paper is original (has not been published previously), not infringing any copyright or other ownership right involving third parties. Once the paper is submitted, the Journal reserves the right to make normative changes, such as spelling and grammar, in order to maintain the language standard, but respecting the author’s style. The published papers become ownership of RECI, considering that all the opinions expressed by the authors are their responsibility. Because we are an open access journal, we allow free use of articles in educational and scientific applications provided the source is cited under the Creative Commons CC-BY license.