Therapeutic potential of chalcones in combating dengue fever: bibliometric analysis

Authors

  • Danúbio Andrade Bezerra Farias Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0009-0009-0009-985X
  • Luiz Francisco Wemmenson Gonçalves Moura Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0000-0001-5854-6709
  • Natália do Vale Canabrava Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0000-0002-4841-8989
  • Francisco Leandro Fernandes Sampaio Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0009-0007-4043-6238
  • José Ítalo Magalhães de Sousa Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0009-0008-7305-6714
  • Vânia Marilande Ceccatto Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Fisiologia Ciências, Programa de Pós-Graduação, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0000-0003-4839-4400
  • Márcia Maria Mendes Marques Duque Universidade Federal do Piauí, Campus Senador Helvídio Nunes de Barros, Piauí, Brasil. https://orcid.org/0000-0001-7661-2570
  • Maria Izabel Florindo Guedes Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Fisiologia Ciências, Programa de Pós-Graduação, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. https://orcid.org/0000-0002-4569-8663

DOI:

https://doi.org/10.17058/reci.v16i.20407

Keywords:

Bibliometric Study, Bibliometrix, Chalcone, Dengue, Aedes aegypti

Abstract

Background and Objectives: Dengue is a viral disease transmitted by the Aedes aegypti mosquito, characterized by rapid spread and global impact. In addition to dengue, this vector transmits Zika and Chikungunya viruses. Given the limited availability of antiviral therapies, the development of new treatments is critical. Chalcone compounds have demonstrated both larvicidal and antiviral potential, making them promising candidates in the fight against these diseases. This study aims to conduct a literature review on the therapeutic potential of chalcones in combating dengue, using bibliometric analysis. Content: The bibliometric analysis was performed using the Scopus database to identify both global and national publications. Data collection involved Boolean search strategies and specific filters, and the retrieved documents were analyzed using the Bibliometrix tool to assess key research trends, collaboration networks, and Brazil’s contribution to the field. The analysis highlights the main research domains, author contributions, institutional affiliations, and publication trends by country. By examining publications from 2006 to 2024, the study identifies the most prominent research areas, leading authors, influential journals, and country-specific contributions. Conclusion: The findings reveal a growing body of scientific literature on chalcones and dengue, with pioneering studies underscoring their antiviral potential. The study also maps global collaboration networks, contributing to advances in antiviral discovery and vector control.

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Author Biographies

  • Danúbio Andrade Bezerra Farias, Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

  • Luiz Francisco Wemmenson Gonçalves Moura, Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

  • Natália do Vale Canabrava, Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

  • Francisco Leandro Fernandes Sampaio, Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

  • José Ítalo Magalhães de Sousa, Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

  • Vânia Marilande Ceccatto, Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Fisiologia Ciências, Programa de Pós-Graduação, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

  • Márcia Maria Mendes Marques Duque, Universidade Federal do Piauí, Campus Senador Helvídio Nunes de Barros, Piauí, Brasil.

    .

  • Maria Izabel Florindo Guedes, Rede Nordeste de Biotecnologia, Programa de Pós-Graduação em Biotecnologia, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil. Fisiologia Ciências, Programa de Pós-Graduação, Universidade Estadual do Ceará, Campus do Itaperi, Fortaleza, Ceará, Brasil.

    .

     

References

1. Kularatne AS, Dalugama C. Dengue Infection: Global Importance, Immunopathology and Management. Clin. Med. (Northfield. Il). 2022, 22 (1), 9–13. https://doi.org/10.7861/clinmed.2021-0791.

2. Almeida e Sá FH, Silva ARN, de Oliveira TJS, et al. Chalcone Identified by in Silico and in Vitro Assays Possesses High Larvicidal Activity against Aedes Aegypti. Acta Trop. 2023, 238, 106791. https://doi.org/10.1016/j.actatropica.2022.106791.

3. Wong JM, Adams LE, Durbin AP, et al. Dengue: A Growing Problem With New Interventions. Pediatrics 2022, 149 (6). https://doi.org/10.1542/peds.2021-055522.

4. Parveen S, Riaz Z, Saeed S, et al. Dengue Hemorrhagic Fever: A Growing Global Menace. J. Water Health 2023, 21 (11), 1632–1650. https://doi.org/10.2166/wh.2023.114.

5. ONU. Opas: epidemia histórica de dengue nas Américas eleva risco para crianças. 2024.

6. Elkhalifa D, Al-Hashimi I, Al Moustafa AE, Khalil A. A Comprehensive Review on the Antiviral Activities of Chalcones. J. Drug Target. 2021, 29 (4), 403–419. https://doi.org/10.1080/1061186X.2020.1853759.

7. Ouyang Y, Li J, Chen X, Fu X, Sun S, Wu Q. Chalcone Derivatives: Role in Anticancer Therapy. Biomolecules 2021, 11 (6), 894. https://doi.org/10.3390/biom11060894.

8. Cheng P, Yang L, Huang X, Wang X, Gong M. Chalcone Hybrids and Their Antimalarial Activity. Arch. Pharm. (Weinheim). 2020, 353 (4). https://doi.org/10.1002/ardp.201900350.

9. Dhaliwal JS, Moshawih S, Goh KW, et al. Pharmacotherapeutics Applications and Chemistry of Chalcone Derivatives. Molecules 2022, 27 (20), 7062. https://doi.org/10.3390/molecules27207062.

10. Gomes M, Muratov E, Pereira M, et al. Chalcone Derivatives: Promising Starting Points for Drug Design. Molecules 2017, 22 (8), 1210. https://doi.org/10.3390/molecules22081210.

11. Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to Conduct a Bibliometric Analysis: An Overview and Guidelines. J. Bus. Res. 2021, 133, 285–296. https://doi.org/10.1016/j.jbusres.2021.04.070.

12. Aria, M, Cuccurullo, C. Bibliometrix : An R-Tool for Comprehensive Science Mapping Analysis. J. Informetr. 2017, 11 (4), 959–975. https://doi.org/10.1016/j.joi.2017.08.007.

13. Hariono M, Choi SB, Roslim RF, et al. Thioguanine-Based DENV-2 NS2B/NS3 Protease Inhibitors: Virtual Screening, Synthesis, Biological Evaluation and Molecular Modelling. PLoS One 2019, 14 (1), e0210869. https://doi.org/10.1371/journal.pone.0210869.

14. Heh CH, Othman R, Buckle MJC, Sharifuddin Y, Yusof R, Rahman N. A. Rational Discovery of Dengue Type 2 Non‐Competitive Inhibitors. Chem. Biol. Drug Des. 2013, 82 (1), 1–11. https://doi.org/10.1111/cbdd.12122.

15. Chee CF, Abdullah I, Buckle MJC, Rahman NA. An Efficient Synthesis of (±)-Panduratin A and (±)-Isopanduratin A, Inhibitors of Dengue-2 Viral Activity. Tetrahedron Lett. 2010, 51 (3), 495–498. https://doi.org/10.1016/j.tetlet.2009.11.030.

16. Kiat TS, Pippen R, Yusof R, Ibrahim H, Khalid N, Rahman, N. A. Inhibitory Activity of Cyclohexenyl Chalcone Derivatives and Flavonoids of Fingerroot, Boesenbergia Rotunda (L.), towards Dengue-2 Virus NS3 Protease. Bioorg. Med. Chem. Lett. 2006, 16 (12), 3337–3340. https://doi.org/10.1016/j.bmcl.2005.12.075.

17. Md-Mustafa ND, Khalid N, Gao H, et al. Transcriptome Profiling Shows Gene Regulation Patterns in a Flavonoid Pathway in Response to Exogenous Phenylalanine in Boesenbergia Rotunda Cell Culture. BMC Genomics 2014, 15 (1), 984. https://doi.org/10.1186/1471-2164-15-984.

18. Koçyiğit-Kaymakçıoğlu B, Beyhan N, Tabanca N, et al. Discovery and Structure Activity Relationships of 2-Pyrazolines Derived from Chalcones from a Pest Management Perspective. Med. Chem. Res. 2015, 24 (10), 3632–3644. https://doi.org/10.1007/s00044-015-1415-8.

19. Mottin M, Caesar LK, Brodsky D, et al. Chalcones from Angelica Keiskei (Ashitaba) Inhibit Key Zika Virus Replication Proteins. Bioorg. Chem. 2022, 120, 105649. https://doi.org/10.1016/j.bioorg.2022.105649.

20. Jeon YJ, Jung SN, Chang H, et al. Artocarpus Altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. Phyther. Res. 2015, 29 (5), 749–756. https://doi.org/10.1002/ptr.5311.

21. Patil SA, Patil V, Patil R, Beaman K, Patil SA. Identification of Novel 5,6-Dimethoxyindan-1-One Derivatives as Antiviral Agents. Med. Chem. (Los. Angeles). 2017, 13 (8). https://doi.org/10.2174/1573406413666170330094822.

22. Patil V, Patil, SA, Patil R, Bugarin A, Beaman K, Patil SA. Exploration of (Hetero)Aryl Derived Thienylchalcones for Antiviral and Anticancer Activities. Med. Chem. (Los. Angeles). 2019, 15 (2), 150–161. https://doi.org/10.2174/1573406414666180524074648.

23. Bharathi A, Roopan SM, Rahuman AA, Rajakumar G. In Vitro Larvicidal and Antioxidant Activity of Dihydrophenanthroline-3-Carbonitriles. Biomed Res. Int. 2014, 2014, 1–8. https://doi.org/10.1155/2014/915797.

24. Santos M, Da Silva Santos F, Ferraz A, et al. Triazole-Chalcones: Lack of Antibacterial, Anti-Candida, and Anti-Dengue Virus Activities. J. Pharm. Negat. Results 2018, 9 (1), 39. https://doi.org/10.4103/jpnr.JPNR_2_18.

25. Ganji LR, Gandhi L, Musturi V, Kanyalkar MA. Design, Synthesis, and Evaluation of Different Scaffold Derivatives against NS2B-NS3 Protease of Dengue Virus. Med. Chem. Res. 2021, 30 (1), 285–301. https://doi.org/10.1007/s00044-020-02660-y.

26. Parida P, Yadav RNS, Dehury B, et al. Novel Insights into the Molecular Interaction of a Panduratin A Derivative with the Non Structural Protein (NS3) of Dengue Serotypes: A Molecular Dynamics Study. Curr. Pharm. Biotechnol. 2017, 18 (9). https://doi.org/10.2174/1389201018666171122122338.

27. Purohit P, Barik D, Agasti S, Panda M, Meher BR. Evaluation of the Inhibitory Potency of Anti-Dengue Phytocompounds against DENV-2 NS2B-NS3 Protease: Virtual Screening, ADMET Profiling and Molecular Dynamics Simulation Investigations. J. Biomol. Struct. Dyn. 2024, 42 (6), 2990–3009. https://doi.org/10.1080/07391102.2023.2212798.

28. Cao V, Sukanadi IP, Loeanurit N, et al. A Sulfonamide Chalcone Inhibited Dengue Virus with a Potential Target at the SAM-Binding Site of Viral Methyltransferase. Antiviral Res. 2023, 220, 105753. https://doi.org/10.1016/j.antiviral.2023.105753.

29. Lima WG, Andrade JT, da Silva Santos FR, et al. Antibacterial, Antifungal, and Antiviral Activities of Chalcone-Bearing Tetrahydropyranyl and 2,4-Dihydroxyl Moieties. Rev. Colomb. Ciencias Químico-Farmacéuticas 2020, 49 (1). https://doi.org/10.15446/rcciquifa.v49n1.87036.

30. Huq AKMM, Roney M, Dubey A, et al. Phenolic Compounds of Theobroma Cacao L. Show Potential against Dengue RdRp Protease Enzyme Inhibition by In-Silico Docking, DFT Study, MD Simulation and MMGBSA Calculation. PLoS One 2024, 19 (3), e0299238. https://doi.org/10.1371/journal.pone.0299238.

31. Musatat AB, Durmuş T, Atahan A. Harnessing High Potential Benzothiazole Chalcones against Dengue Virus NS5 Protein: A Multi-Faceted Theoretical Study through Molecular Docking, ADME, and DFT. Arch. Biochem. Biophys. 2024, 761, 110171. https://doi.org/10.1016/j.abb.2024.110171.

32. Ali SI, Sheikh WM, Rather MA, Venkatesalu V, Muzamil Bashir S, Nabi SU. Medicinal Plants: Treasure for Antiviral Drug Discovery. Phyther. Res. 2021, 35 (7), 3447–3483. https://doi.org/10.1002/ptr.7039.

33. Marinescu M. Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities. Antibiotics 2021, 10 (8), 1002. https://doi.org/10.3390/antibiotics10081002.

34. Poonia N, Kumar A, Kumar V, Yadav M, Lal K. Recent Progress in 1H-1,2,3-Triazoles as Potential Antifungal Agents. Curr. Top. Med. Chem. 2021, 21 (23), 2109–2133. https://doi.org/10.2174/1568026621666210913122828.

35. Melino S, Paci M. Progress for Dengue Virus Diseases. FEBS J. 2007, 274 (12), 2986–3002. https://doi.org/10.1111/j.1742-4658.2007.05831.x.

36. Ali F, Chorsiya A, Anjum V, Khasimbi S, Ali A. A Systematic Review on Phytochemicals for the Treatment of Dengue. Phyther. Res. 2021, 35 (4), 1782–1816. https://doi.org/10.1002/ptr.6917.

37. Shawon J, Akter Z, Hossen MM, et al. A. Current Landscape of Natural Products against Coronaviruses: Perspectives in COVID-19 Treatment and Anti-Viral Mechanism. Curr. Pharm. Des. 2020, 26 (41), 5241–5260. https://doi.org/10.2174/1381612826666201106093912.

38. Pereira RS, Santos FCP, Campana PRV, et al. Natural Products and Derivatives as Potential Zika Virus Inhibitors: A Comprehensive Review. Viruses 2023, 15 (5), 1211. https://doi.org/10.3390/v15051211.

39. Saha C, Naskar R, Chakraborty S. Antiviral Flavonoids: A Natural Scaffold with Prospects as Phytomedicines against SARS-CoV2. Mini-Reviews Med. Chem. 2024, 24 (1), 39–59. https://doi.org/10.2174/1389557523666230503105053.

40. Sardari S, Rafieian-Kopaei M, Malekmohammad K, Sewell RDE. Review of Phytochemical Compounds as Antiviral Agents Against Arboviruses from the Genera Flavivirus and Alphavirus. Curr. Drug Discov. Technol. 2020, 17 (4), 484–497. https://doi.org/10.2174/1570163817666200122102443.

41. Sobhia ME, Ghosh K, Singh A, et al. A Multi-Perspective Review on Dengue Research. Curr. Drug Targets 2019, 20 (15), 1550–1562. https://doi.org/10.2174/1389450120666190724145937.

42. Singh S, Sharma S, Sharma H. Naturally Occurring Herbs and Their Bioactive Metabolites: Potential Targets and Signaling Pathways of Antiviral Agents. Endocrine, Metab. Immune Disord. - Drug Targets 2023, 23 (12), 1505–1537. https://doi.org/10.2174/1871530323666230622122901.

43. Laengle S, Merigó JM, Miranda J, et al. Forty Years of the European Journal of Operational Research: A Bibliometric Overview. Eur. J. Oper. Res. 2017, 262 (3), 803–816. https://doi.org/10.1016/j.ejor.2017.04.027.

44. Chuang YT, Lin YL, Lin JY. Licochalcone A Regulates Viral IRES Activity to Inhibit Enterovirus Replication. Antiviral Res. 2024, 221, 105755. https://doi.org/10.1016/j.antiviral.2023.105755.

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Published

2026-09-01

Issue

Vol. 16 (2026)

Section

REVIEW ARTICLE

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Copyright (c) 2026 Danúbio Andrade Bezerra Farias, Luiz Francisco Wemmenson Gonçalves Moura, Natália do Vale Canabrava, Francisco Leandro Fernandes Sampaio, José Ítalo Magalhães de Sousa, Vânia Marilande Ceccatto, Márcia Maria Mendes Marques Duque, Maria Izabel Florindo Guedes

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How to Cite

Andrade Bezerra Farias, D. ., Francisco Wemmenson Gonçalves Moura, L. ., do Vale Canabrava, N., Leandro Fernandes Sampaio, F. ., Ítalo Magalhães de Sousa, J. ., Marilande Ceccatto, V. ., Maria Mendes Marques Duque, M. ., & Izabel Florindo Guedes, M. (2026). Therapeutic potential of chalcones in combating dengue fever: bibliometric analysis. Revista De Epidemiologia E Controle De Infecção, 16. https://doi.org/10.17058/reci.v16i.20407