Anosmia in Covid-19 and its association with chronic diseases and infectious disease symptoms
DOI:
https://doi.org/10.17058/reci.v15i4.19699Keywords:
SARS-CoV-2, Pandemic, Smell disorders, Ageusia, DysgeusiaAbstract
Background and Objectives: Anosmia in Covid-19 may indicate a more favorable prognosis, highlighting the importance of understanding associated factors to support clinical decisions. This study aimed to analyze the prevalence and factors related to anosmia in individuals tested for Covid-19. Methods: Data from a university extension program that provided molecular testing services for Covid-19 diagnosis were used. Data collected between April 2020 and January 2023 were used. The chi-square test (p<0.05) was used by grouping participants according to the molecular test result: positive and negative for Covid-19. Results: A total of 6.5% (n=2252) of the population had anosmia, of which 1228 tested positive for Covid-19. Most participants with anosmia were adult females. There was a significant association between Covid-19 anosmia and the variant change milestone in February 2021. Among chronic diseases in individuals with anosmia and Covid-19, there was a significant association (p<0.05) with high blood pressure and diabetes. Among the symptoms of individuals with anosmia and Covid-19, ageusia, headache, and cough were directly associated; while runny nose, sore throat, dyspnea, diarrhea, and vomiting were inversely associated (p<0.05). Conclusion: In this study, chronic diseases related to Covid-19 anosmia included high blood pressure and diabetes, and the associated symptoms were ageusia, headache, and cough. Runny nose, sore throat, dyspnea, diarrhea, and vomiting appeared less frequently than expected in individuals with anosmia and Covid-19.
Downloads
References
1. Meng X, Pan Y. COVID-19 and anosmia: The story so far. Ear, Nose &; Throat Journal. 2024;103:NP312–NP320. http://dx.doi.org/10.1177/01455613211048998.
2. Meng X, Deng Y, Dai Z, et al. COVID-19 and anosmia: A review based on up-to-date knowledge. American Journal of Otolaryngology. 2020;41:102581. http://dx.doi.org/10.1016/j.amjoto.2020.102581.
3. Petry LR, Gomes CF, Valério MH, et al. Fatores sociodemográficos, sintomas e comorbidades associados à COVID-19 em município do Sul do Brasil. Comunicação em Ciências da Saúde. 2022;33. http://dx.doi.org/10.51723/ccs.v33i03.1259.
4. Siswanto JLJ, Kalanjati VP, Soetjipto S, et al. Anosmia, dysgeusia, and comorbidity in COVID-19 patients with respiratory tract manifestations. Jurnal Respirasi. 2023;9:188–193. http://dx.doi.org/10.20473/jr.v9-i.3.2023.188-193.
5. Mishra P, Gowda V, Dixit S, et al. Prevalence of new onset anosmia in COVID-19 patients: Is the trend different between European and Indian population? Indian Journal of Otolaryngology and Head & Neck Surgery. 2020;72:484–487. http://dx.doi.org/10.1007/s12070-020-01986-8.
6. Butowt R, Bilińska K, von Bartheld C. Why does the omicron variant largely spare olfactory function? implications for the pathogenesis of anosmia in coronavirus disease 2019. The Journal of Infectious Diseases. 2022;226:1304–1308. http://dx.doi.org/10.1093/infdis/jiac113.
7. Lechien JR, Wajsblat S, Horoi M, et al. Comparison of prevalence and evolution of COVID-19 olfactory disorders in patients infected by D614 (wild) and B.1.1.7. Alpha variant: a brief report. European Archives of Oto-Rhino-Laryngology. 2023;280:3461–3467. http://dx.doi.org/10.1007/s00405-023-07923-z.
8. Mendonça CV, Mendes Neto JA, Suzuki FA, et al. Olfactory dysfunction in COVID-19: a marker of good prognosis? Brazilian Journal of Otorhinolaryngology. 2022;88:439–444. http://dx.doi.org/10.1016/j.bjorl.2020.12.002.
9. Hendawy E, El-Anwar MW, Elghamry RM, et al. Anosmia in COVID-19 Patients: Can we predict the severity of chest manifestations? International Archives of Otorhinolaryngology. 2023;27:e143–e151.http://dx.doi.org/10.1055/s-0042-1758716.
10. Worldometer. Coronavirus. https://www.worldometers.info/coronavirus/country/brazil/.
11. Ruoso TF, Vilande FL, Ochoa CF, Graichen DÂS, Batista ÂG. Programa de extensão universitária UFSM-Detecta: Ações de educação em saúde e diagnóstico molecular para o enfrentamento da COVID-19. Revista Brasileira de Extensão Universitária. 2024;15:95–109. https://doi.org/10.29327/2303474.15.1-9.
12. Alharbi H, You S, Katz J. Should anosmia and dysgeusia be a concern for oral and maxillofacial surgeons during the COVID-19 pandemic? Oral and Maxillofacial Surgery. 2021;26:105–111. http://dx.doi.org/10.1007/s10006-021-00965-9.
13. Alkholaiwi FM, Altamimi AF, Almalki HH, et al. Olfactory dysfunction among patients with COVID-19. Saudi Medical Journal. 2023;44:1085–1103. http://dx.doi.org/10.15537/smj.2023.44.11.20230264.
14. Valletta RC, Camargo LA de, Rodrigues SO, et al. Olfactory dysfunction in the scenario of COVID-19 pandemic in patients screened by the telemonitoring. Einstein (São Paulo). 2021;19. http://dx.doi.org/10.31744/einstein_journal/2021ao6204.
15. Krishnakumar HN, Momtaz DA, Sherwani A, et al. Pathogenesis and progression of anosmia and dysgeusia during the COVID-19 pandemic. European Archives of Oto-Rhino-Laryngology. 2022;280:505–509. http://dx.doi.org/10.1007/s00405-022-07689-w.
16. Dezordi FZ, Silva Júnior JVJ, Ruoso TF, et al. Higher frequency of interstate over international transmission chains of SARS-CoV-2 virus at the Rio Grande do Sul - Brazil state borders. Virus Research. 2025;351:199500. https://doi.org/10.1016/j.virusres.2024.199500
17. Vaira LA, De Vito A, Lechien JR, et al. New onset of smell and taste loss are common findings also in patients with symptomatic COVID‐19 after complete vaccination. The Laryngoscope. 2021;132:419–421. http://dx.doi.org/10.1002/lary.29964.
18. Zhao Y, Liu Y, Yi F, et al. Type 2 diabetes mellitus impaired nasal immunity and increased the risk of hyposmia in COVID-19 mild pneumonia patients. International Immunopharmacology. 2021;93:107406. http://dx.doi.org/10.1016/j.intimp.2021.107406.
19. Púa Torrejón RC, Ordoño Saiz MV, González Alguacil E, et al. Smell and taste dysfunction in pediatric patients with SARS-CoV-2 infection. Pediatric Neurology. 2022;136:28–33. http://dx.doi.org/10.1016/j.pediatrneurol.2022.07.006.
20. Maheswaran T, Abikshyeet P, Sitra G, et al. Gustatory dysfunction. Journal of Pharmacy and Bioallied Sciences. 2014;6:30. http://dx.doi.org/10.4103/0975-7406.137257.
21. Desai M, Oppenheimer J. The importance of considering olfactory dysfunction during the COVID-19 pandemic and in clinical practice. The Journal of Allergy and Clinical Immunology: In Practice. 2021;9:7–12. http://dx.doi.org/10.1016/j.jaip.2020.10.036.
22. Mendonça Filho VCM, de Oliveira AG, Maia I de FVC, et al. COVID-19 in the nervous system: physiopathology and neurological manifestations. Arquivos de Neuro-Psiquiatria. 2023;81:756–763. http://dx.doi.org/10.1055/s-0043-1769123.
23. Sampaio Rocha‐Filho PA. Headache associated with COVID‐19: Epidemiology, characteristics, pathophysiology, and management. Headache: The Journal of Head and Face Pain. 2022;62:650–656. http://dx.doi.org/10.1111/head.14319.
24. Konstantinidis I, Tsakiropoulou E, Hähner A, et al. Olfactory dysfunction after coronavirus disease 2019 (COVID‐19) vaccination. International Forum of Allergy & Rhinology. 2021;11:1399–1401. http://dx.doi.org/10.1002/alr.22809.
25. Butowt R, von Bartheld CS. Anosmia in COVID-19: Underlying mechanisms and assessment of an olfactory route to brain infection. The Neuroscientist. 2020;27:582–603. http://dx.doi.org/10.1177/1073858420956905.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Fernanda Lopes Vilande, Terimar Facin Ruoso, Daniel Ângelo Sganzerla Graichen, Angela Giovana Batista

This work is licensed under a Creative Commons Attribution 4.0 International License.
The author must state that the paper is original (has not been published previously), not infringing any copyright or other ownership right involving third parties. Once the paper is submitted, the Journal reserves the right to make normative changes, such as spelling and grammar, in order to maintain the language standard, but respecting the author’s style. The published papers become ownership of RECI, considering that all the opinions expressed by the authors are their responsibility. Because we are an open access journal, we allow free use of articles in educational and scientific applications provided the source is cited under the Creative Commons CC-BY license.