Spatio-temporal analysis of congenital syphilis in Rio Grande do Norte, Brazil, from 2008 to 2022
DOI:
https://doi.org/10.17058/reci.v15i3.19996Keywords:
Nursing. Congenital Syphilis. Vertical Transmission of Infectious Diseases. Spatial Analysis. Time Series Studies.Abstract
Background and Objectives: Rio Grande do Norte state is experiencing an epidemic of congenital syphilis cases, with an average incidence above the national rate. In this context, this study aims to identify the Health Regions of Rio Grande do Norte most affected by congenital syphilis through spatial analysis and, from there, define the temporal trend of infection in these areas. Methods: This is an ecological study using secondary data, using spatial analysis techniques, and temporal trends of congenital syphilis in Rio Grande do Norte from 2008 to 2022. Results: The incidence of congenital syphilis in 2022 reached 525 new cases in the state, approximately 100 fewer cases compared to 2021. Of these, the 7thhealth region had a substantially higher average than the other regions. The 3rd health region has the highest average number of congenital syphilis cases per 1,000 live births in the territory, with 25.51 cases. Regarding the temporal trend, the most significant increase is expected in the 8th, 3rd, and 7th health regions, respectively. Conclusion: A greater incidence of congenital syphilis exposure was found in the 1st, 3rd, 7th, and 8th health regions. Given the data studied, an increase in these health regions is expected, which may result in service overload. Therefore, appropriate management of infected pregnant women should be reinforced in Primary Care, as well as investment in prevention and health education actions.
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1. Pinheiro YT, Silva RAR. Has the COVID-19 pandemic affected the epidemiology of syphilis in Brazil? Rev Bras Ginecol Obstet [Internet]. 2022 Jun;44(6):629–30. Available from: doi:10.1055/s-0042-1748024
2. Ferreira TLFS, Costa KTS, Silva RAR, et al. Infant mortality in Brazil from 2000 to 2020: a study of spatial and trend analysis. BMC Public Health. 2025;25:948. doi:10.1186/s12889-025-22066-y
3. Santiago JC, Silva HL, Lima DM, Araújo AK, Moreira OA, Silva RA. Health care for people with syphilis: an evaluative study. Online Braz J Nurs. 2020;19(1):e20206316. doi:10.17665/1676-4285.20206316
4. Assunção MG, Botelho EP, Ferreira GRON, et al. LEARNHIV: development and validation of a mobile application for primary health care nurses focused on HIV care/prevention. BMC Nurs. 2023;22:419. doi:10.1186/s12912-023-01579-0
5. Brasil. Ministério da Saúde. Portaria nº 542, de 22 de dezembro de 1986. Dispõe sobre o Sistema Nacional de Vigilância Epidemiológica e dá outras providências. Diário Oficial da República Federativa do Brasil, Brasília (DF), 1986 dez 22; Seção 1:19827-19827.
6. Raimundo DML, Silva RAR, Pinheiro YT, Menezes HF, Santos WN, Holanda JRR, Correia RBF, et al. Congenital syphilis: time trend analysis and projection of cases. Acta Paul Enferm 2025;38:eAPE0003054.
7. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Boletim Epidemiológico de Sífilis. Brasília: Ministério da Saúde; 2023. 56 p.
8. Instituto Brasileiro de Geografia e Estatística (IBGE). Censo Brasileiro de 2010. Rio de Janeiro: IBGE, 2012.
9. National Cancer Institute. Joinpoint Trend Analysis Software. 2020. Disponível em: https://surveillance.cancer.gov/joinpoint/.
10. Brasil. Conselho Nacional de Saúde. Resolução nº 466, de 12 de dezembro de 2012. Brasília, 2012. Disponível em: http://www.conselho.saude.gov.br/web_comissoes/conep/index.html Acesso em 04 jan.
11. SESAP/RN. Secretaria de Saúde Pública do Rio Grande do Norte. Ministério da Saúde. Plano Estadual de Saúde do RN 2020 - 2023. 2020 [citado 2024 out 09]. Disponível em: https://www.conass.org.br/wp-content/uploads/2021/04/Plano-Estadual-Sau%CC%81de_RN_2020_2023-1.pdf.
12. Dantas JDC, Lopes RH, Marinho CDSR, Pinheiro YT, Silva RARD. The Use of Spatial Analysis in Syphilis-Related Research: Protocol for a Scoping Review. JMIR Res Protoc. 2023;25(12):e43243. https://doi.org/10.2196/43243.
13. Pinho ECC, Silva JJG, Ramos AMPC, et al. Social and individual vulnerability factors associated with syphilis among populations living on islands in the Brazilian Amazon. BMC Infect Dis. 2024; 24:23. https://doi.org/10.1186/s12879-023-08955-w
14. Dantas JC, Marinho CDSR, Pinheiro YT, Ferreira MÂF, Silva RAR. Spatial Distribution of Gestational Syphilis in Brazil: Socioeconomic and Health Services Inequalities. Am J Trop Med Hyg. 2023;109(1):42-49. https://doi.org/10.4269/ajtmh.22-0449.
15. Pinheiro YT, Dantas JDC, Holanda JRR, Feitosa ADNA, Silva RAR. Epidemiology of Syphilis in Pregnancy and Congenital Syphilis in Brazil and the Risk or Associated Factors: Protocol for a Systematic Review. JMIR Res Protoc. 2024.4;(13):e50702. https://doi.org/10.2196/50702.
16. Dantas JDC, Marinho CDSR, Pinheiro YT, Ferreira MÂF, da Silva RAR. Temporal trend and factors associated with spatial distribution of congenital syphilis in Brazil: An ecological study. Front Pediatr. 2023; 11:1109271. https://doi.org/10.3389/fped.2023.1109271
17. Correia RBF, Mourad RP, Dantas JDC, Silva RARD. Barriers and Facilitators Affecting Access to Health Care for People With Syphilis: Protocol for a Scoping Review. JMIR Res Protoc. 2024;15(13):e63561. https://doi.org/10.2196/63561.
18. Raimundo DML, Sousa GJB, Silva ABP, Almino RHSC, Prado NCC, Silva RAR. Spatial analysis of congenital syphilis in the State of Rio Grande do Norte, between 2008 and 2018. Rev Esc Enferm USP. 2021;55:e20200578. https://doi.org/10.1590/1980-220X-REEUSP-2020-0578
19. Dantas JD, Marinho CD, Pinheiro YT, Silva RAR. Temporal trend of gestational syphilis between 2008 and 2018 in brazil: association with socioeconomic and health care factors. Int J Environ Res Public Health. 2022;19(24):16456.
20. Pinho ECC, Galvão JJDS, Martins WM, Goncalves FE, Aben-Athar CYUP, da Silva RAR, et al. Knowledge about sexually transmitted infections and associated factors among Brazilian Riverside People. Nurs Health Sci. 2024;26:e70002. doi:10.1111/nhs.70002
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Copyright (c) 2025 Dhyanine Morais de Lima Raimundo, Rita de Cássia Azevedo Constantino, Richardson Augusto Rosendo da Silva, Angelo Maximo Soares de Araujo Filho, Ketyllem Tayanne da Silva Costa, Harlon França de Menezes, Ana Elza Oliveira de Mendonça
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