Estrategias para el control de infecciones en unidades de hospitalización neonatal: una revisión integradora
DOI:
https://doi.org/10.17058/reci.v16i.20488Palabras clave:
Control de Infecciones, Protocolos Clínicos, Unidades de Cuidado Intensivo NeonatalResumen
Justificación y Objetivo: Las infecciones asociadas a la atención de la salud (IAAS) en unidades de cuidados intensivos neonatales (UCIN) representan un reto para la calidad y seguridad de la atención neonatal, especialmente en neonatos prematuros y de bajo peso, cuya vulnerabilidad inmunológica y exposición a procedimientos invasivos aumentan el riesgo de morbilidad y mortalidad. El objetivo de este estudio fue analizar las principales estrategias utilizadas para controlar las IAAS en UCIN, destacando su efectividad e impacto en la mejora de la atención neonatal. Métodos: Revisión integradora realizada en LILACS, SciELO y PubMed, que incluyó artículos originales publicados entre 2019 y marzo de 2025. Los estudios fueron seleccionados y organizados considerando título, autores, país, año de publicación, intervenciones propuestas y resultados. Conclusión: Los hallazgos revelaron que la adherencia a la higiene de manos, junto con capacitación y estrategias multimodales, representa una de las medidas más eficaces y de menor costo para prevenir IAAS. La implementación de programas de administración de antimicrobianos y de protocolos para Staphylococcus aureus resistente a la meticilina (SARM) e infecciones asociadas a dispositivos invasivos mostró un impacto en la reducción de las tasas de infección y del tiempo de hospitalización. Iniciativas como el SAFH y el Comprehensive Unit-based Safety Program (CUSP) mejoraron la cultura de seguridad del paciente y la atención neonatal. La integración de estrategias de control, educación continua y compromiso interdisciplinario es clave para mejorar la calidad de la atención, reducir IAAS en UCIN y promover mayor seguridad y mejores resultados en neonatos críticos.
Descargas
Referencias
1. Aguiar JN, de Carvalho IPSF, Domingues RAS, Souto Maior MDCL, Luiza VL, Barreto JOM, Tavares NUL. Evolução das políticas brasileiras de saúde humana para prevenção e controle da resistência aos antimicrobianos: revisão de escopo. Rev Panam Salud Pública. 2023;47:e77. https://doi.org/10.26633/RPSP.2023.77
2. Agência Nacional de Vigilância Sanitária. Programa Nacional de Prevenção e Controle de Infecções Relacionadas à Assistência à Saúde 2021 a 2025 [Internet]. Brasília: Anvisa; 2021. Disponível em: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/publicacoes/pnpciras_2021_2025.pdf
3. World Health Organization. Guidelines on core components of infection prevention and control programmes at the national and acute health care facility level [Internet]. Geneva: WHO; 2016. Disponível em: https://www.who.int/publications/i/item/9789241549929
4. Kiffer CRV, Cuba GT, Fortaleza CMCB, Padoveze MC, Pignatari ACC. Exploratory model for estimating occupation-day costs associated to hospital related infections based on data from national prevalence project: IRAS Brasil Project [Internet]. J Infect Control. 2015;4:30–3. Disponível em: http://jic.abih.net.br/index.php/jic/article/view/97/pdf_1
5. Agência Nacional de Vigilância Sanitária. Boletim Segurança do Paciente e qualidade em Serviços de Saúde nº 32: Avaliação Nacional dos indicadores de Infecções Relacionadas à Assistência em Saúde e Resistência Microbiana [Internet]. Brasília: Anvisa; 2024. Disponível em: https://app.powerbi.com/view?r=eyJrIjoiOTAyZjNlZDAtNDVkMC00MjY5LTg0MjQtNTQ0M2IyNWVkNGVhIiwidCI6ImI2N2FmMjNmLWMzZjMtNGQzNS04MGM3LWI3MDg1ZjVlZGQ4MSJ9
6. Agência Nacional de Vigilância Sanitária. Manual Pediatria – Prevenção e Controle de Infecção Hospitalar [Internet]. Brasília: Anvisa; 2006. Disponível em: https://biblioteca.cofen.gov.br/wp-content/uploads/2015/01/Pediatria-prevencao-e-controle-de-infeccao-hospitalar.pdf
7. Walty CMRF, Henriques NL, Coimbra NMM, et al. Actions caring and essential needs of premature infants after hospital discharge: scoping review. Esc Anna Nery. 2021;25(4):e20200412. https://doi.org/10.1590/2177-9465-EAN-2020-0412
8. Agência Nacional de Vigilância Sanitária. Critérios Diagnósticos de Infecção Relacionada à Assistência à Saúde [Internet]. Brasília: Anvisa; 2017. Disponível em: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/publicacoes/caderno-2-criterios-diagnosticos-de-infeccao-relacionada-a-assistencia-a-saude.pdf/view
9. Yeshiwas AG, Bayeh GM, Tsega TD, Tsega SS, Gebeyehu AA, Asmare ZA, et al. A mixed-method study on antimicrobial resistance infection drivers in neonatal intensive care units: pathways, risks, and solutions. Antimicrob Resist Infect Control. 2025;14(1):15. https://doi.org/10.1186/s13756-025-01520-x
10. Souza MT, Silva MD, Carvalho R. Integrative review: what is it? How to do it?. Einstein (Sao Paulo). 2010;8(1):102–6. https://doi.org/10.1590/S1679-45082010RW1134
11. Calo CN, Carvalho CJ, Patino MC. Systematic reviews: a brief overview. J Bras Pneumol. 2020;46(5):e20200475. https://doi.org/10.36416/1806-3756/e20200475
12. Lopes GC. Adesão à higienização das mãos: impacto de uma intervenção educativa em unidade de terapia intensiva neonatal [Internet]. São Paulo: Universidade de São Paulo; 2019. Disponível em: https://repositorio.usp.br/item/002948520
13. Rakshit P, Nagpal N, Sharma S, Mishra K, Kumar A, Banerjee T. Effects of implementation of healthcare associated infection surveillance and interventional measures in the neonatal intensive care unit: Small steps matter. Indian J Med Microbiol. 2023;44:100369. https://doi.org/10.1016/j.ijmmb.2023.100369
14. Dramowski A, Erasmus LM, Aucamp M, Fataar A, Cotton MF, Coffin SE, et al. SafeHANDS: A Multimodal Hand Hygiene Intervention in a Resource-Limited Neonatal Unit. Trop Med Infect Dis. 2022;8(1):27. https://doi.org/10.3390/tropicalmed8010027
15. Saavedra Bravo MA, Santos GCSD, Petenate S, Westphal PJ, Souza LGA, Marques RG, et al. Adapting lean management to prevent healthcare-associated infections: a low-cost strategy involving Kamishibai cards to sustain bundles’ compliance. Int J Qual Health Care. 2023;35(4):mzad100. https://doi.org/10.1093/intqhc/mzad100
16. Cowden C, Mwananyanda L, Hamer DH, Coffin SE, Kapasa ML Machona S, et al. Healthcare worker perceptions of the implementation context surrounding an infection prevention intervention in a Zambian neonatal intensive care unit. BMC Pediatr. 2020;20(1):432. https://doi.org/10.1186/s12887-020-02323-2
17. Kallimath A, Patnaik SK, Malshe N, Suryawanshi P, Singh P, Gareghat R, et al. Quality improvement initiative “S-A-F-H” to reduce healthcare-associated neonatal sepsis in a tertiary neonatal care unit. BMJ Open Qual. 2024;13(Suppl 1):e002336. https://doi.org/10.1136/bmjoq-2023-002336
18. Johnson J, Latif A, Randive B, Kadam A, Rajput U, Kinikar A, et al. Implementation of the Comprehensive Unit-Based Safety Program to Improve Infection Prevention and Control Practices in Four Neonatal Intensive Care Units in Pune, India. Pediatr Front. 2022;6(9):794637. https://doi.org/10.3389/fped.2021.794637
19. Lima CSSDC, Rocha HAL, Araújo DABS, Silva C. Determinants of late neonatal nosocomial infection: a case-control study in Ceará. Rev Saúde Pública. 2022;56:40. https://doi.org/10.11606/s1518-8787.2022056003291
20. Araujo da Silva AR, Almeida AT, Arantes IV, de Oliveira JVM, Schwarzer LT. Controle de infecções relacionadas à assistência à saúde por bactérias Gram-negativas resistentes à carbapenêmicos em unidade de tratamento intensivo neonatal do Rio de Janeiro. Rev Epidemiol Control Infec. 2020;10(2). https://doi.org/10.17058/jeic.v10i2.14018
21. Zini T, Miselli F, D'Esposito C, Fidanza L, Costantini RC, Corso L, et al. Sustaining the Continued Effectiveness of an Antimicrobial Stewardship Program in Preterm Infants. Trop Med Infect Dis. 2024;9(3):59. https://doi.org/10.3390/tropicalmed9030059
22. Huang H, Ran J, Yang J, Li P, Zhuang G. Impact of MRSA Transmission and Infection in a Neonatal Intensive Care Unit in China: A Bundle Intervention Study during 2014–2017. Biomed Res Int. 2019;2019:5490413. https://doi.org/10.1155/2019/5490413
23. Liu J, Fang Z, Yu Y, Ding Y, Liu Z, Zhang C, et al. Pathogens distribution and antimicrobial resistance in bloodstream infections in twenty-five neonatal intensive care units in China, 2017–2019. Antimicrob Resist Infect Control. 2021;10(1):121. https://doi.org/10.1186/s13756-021-00989-6
24. Silva GLVD, Xavier HMD. Infecções Relacionadas à Assistência à Saúde em neonatos com peso menor que 1500g: etiologia, fatores de risco e formas de prevenção. J Infect Control [Internet]. 2020;9(4):265. Disponível em: https://jic-abih.com.br/index.php/jic/article/view/345/pdf
25. Ferorelli D, Goffredo VM, Graziano E, Mastrapasqua M, Telegrafo M, Vinci A et al. Quality improvement in neonatal care through enhanced patient safety and clinical risk management: a before-and-after study about neonatal sepsis. Front Med (Lausanne). 2024;11:1430853. https://doi.org/10.3389/fmed.2024.1430853
26. Fenny AP, Otieku E, Labi KA, Asante FA, Enemark U. Cost-effectiveness analysis of alcohol handrub for the prevention of neonatal bloodstream infections: Evidence from HAI-Ghana study. PLoS One. 2022;17(3):e0264905. https://doi.org/10.1371/journal.pone.0264905
27. Dail RB, Everhart KC, Hardin JW, Chang W, Kuehn D, Iskersky V, Fisher K, et al. Predicting Infection in Very Preterm Infants: A Study Protocol. Nurs Res. 2021;70(2):142. https://doi.org/10.1097/NNR.0000000000000483
28. Götting T, Reuter S, Jonas D, Hentschel R , Henneke P, Klotz D, et al. Protocol for a prospective cohort study: Prevention of Transmissions by Effective Colonisation Tracking in Neonates (PROTECT-Neo). BMJ Open. 2020;10(9):e034068. https://doi.org/10.1136/bmjopen-2019-034068
29. Söderquist Kruth S, Persad E, Rakow A. Probiotic supplements effect on feeding tolerance, growth and neonatal morbidity in extremely preterm infants: a systematic review and meta-analysis. Nutrients. 2025;17(7):1228. https://doi.org/10.3390/nu17071228
30. Han J, Ren YF, Zhang P, Fang CF, Yang L, Zhou S, Ji Z. The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis and related mortality: results from an umbrella meta-analysis on meta-analyses of randomized controlled trials. BMC Gastroenterol. 2025;25(1):245. https://doi.org/10.1186/s12876-025-03788-0
31. Abdullahi AM, Zhao S, Xu Y. Efficacy of probiotic supplementation in preventing necrotizing enterocolitis in preterm infants: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2025;38(1):2485215. https://doi.org/10.1080/14767058.2025.2485215
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2026 Izabelle de Menezes Siqueira, Isabela Lorencini Santos, Murilo Soares Costa

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
The author must state that the paper is original (has not been published previously), not infringing any copyright or other ownership right involving third parties. Once the paper is submitted, the Journal reserves the right to make normative changes, such as spelling and grammar, in order to maintain the language standard, but respecting the author’s style. The published papers become ownership of RECI, considering that all the opinions expressed by the authors are their responsibility. Because we are an open access journal, we allow free use of articles in educational and scientific applications provided the source is cited under the Creative Commons CC-BY license.