Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections

Authors

  • Lisiane Martins Volcão Universidade Federal de Rio Grande
  • Juliano Pereira Lacava Universidade Federal de Rio Grande
  • Ivy Bastos Ramis Universidade Federal de Rio Grande
  • Daniela Fernandes Ramos Universidade Federal de Pelotas
  • Gustavo Souto Damati Hospital Universitário Dr. Miguel Riet Corrêa Jr.
  • Carla Vitola Gonçalves Universidade Federal de Pelotas
  • Pedro Eduardo Almeida da Silva Universidade Federal de Rio Grande
  • Andrea von Groll Universidade Federal de Rio Grande

DOI:

https://doi.org/10.17058/reci.v6i1.6574

Abstract

Background and Objectives: Fluoroquinolones represent a class of amtimicrobials which isfrequently prescribed for the treatment of urinary tract infections (UTIs) of both hospital and community origin. This study aims, to determine the frequency and the factors associated with resistance to ciprofloxacin and levofloxacin in gram-negative bacilli isolated from patients with UTIs treated in a hospital in southern Brazil. Methods: It was performed a transversal and analytical study based on cases of urinary tract infection caused by gram-negative bacteria (GNB) from patients at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande/RS from August 2012 to July 2013. Independent variables such as the age and sex of patients, source of infection of the UTI and the characteristics of the bacterial isolates were analyzed. Results: Of the 562 GNB isolated andanalyzed, the total frequencies of ciprofloxacin and levofloxacin resistance were, respectively, 25.5% and 23.3%, 62.6% community origin and 59% in hospital origin. The risk factors associated with ciprofloxacin and levofloxacin resistance were male patients, infections acquired in the hospital, longer hospitalization times, and the presence of extended spectrum β-lactamases (ESBLs) in the clinical isolates. Conclusions:The results showed strong association between GNB resistancewith the time spent in the hospital and the presence of ESBLs. To control antibiotic resistance andthe reduction the costs in public health, it is necessary that thehospitals have a strong policy ofcontinues vigilanceof the use of and of the resistance of antibiotics. KEYWORDS: Bacteria. Fluoroquinolones. Cross Infection.

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Published

2016-01-04

Issue

Vol. 6 No. 1 (2016)

Section

ORIGINAL ARTICLE

License

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How to Cite

Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections. (2016). Revista De Epidemiologia E Controle De Infecção, 6(1), 18-23. https://doi.org/10.17058/reci.v6i1.6574