Dengue mortality and social vulnerability in Brazilian macro-regions: an ecological study from 2019 to 2023

Authors

DOI:

https://doi.org/10.17058/reci.v16i.20656

Keywords:

Dengue, Social Vulnerability, Mortality, Observational Studies, Ecological Studies

Abstract

Background and Objectives: Arboviruses represent a significant threat to global public health, affecting billions of people. Among them, dengue stands out as an acute and debilitating infection, with a significant impact in Brazil. This study aims to analyze dengue mortality and its association with the Social Vulnerability Index (SVI) across Brazilian macro-regions between 2019 and 2023. Methods: An ecological, observational, and descriptive study was conducted using data from the Mortality Information System (SIM/DATASUS) and the Social Vulnerability Atlas, aggregated by macro-region and year. Deaths due to dengue (ICD-10 codes A90 and A91) were analyzed, and incidence rates, mortality rates, and proportional mortality were calculated. The Shapiro-Wilk normality test, Kruskal-Wallis test, and Spearman correlation were used to assess the association with the SVI. Results: Between 2019 and 2023, dengue-related deaths were analyzed across Brazilian macro-regions, with the highest absolute concentration observed in the Southeast region (median of 417 deaths; IQR 200–506). The Central-west showed the highest proportional mortality (0.0021; IQR 0.0017–0.0024). Statistically significant differences were observed between macro-regions (p < 0.05). No statistically significant correlation was found between SVI and proportional dengue mortality (r = -0.21; p = 0.32). Conclusion: Dengue mortality showed a heterogeneous distribution in Brazil between 2019 and 2023. The association with the SVI was not statistically significant, suggesting the influence of other structural and healthcare-related factors at the macro-regional level.

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Author Biographies

  • Marina Henriques Amaral, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.

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  • Giovanna Xavier Toledo , Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.

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  • Edna Lúcia Campos Wingester, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.

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  • Anna Carolina Vieira Felício, Hospital Municipal de Contagem, Contagem, Minas Gerais, Brasil.

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  • Henrique Amaral Brasil, Hospital Felício Rocho, Belo Horizonte, Minas Gerais, Brasil.

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References

1. Junior JBS, Massad E, Lobao-Neto A, et al. Epidemiology and costs of dengue in Brazil: a systematic literature review. Int J Infect Dis 2022; 122:521–8. https://doi.org/10.1016/j.ijid.2022.06.050

2. Bhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue. Nature 2013; 496:504–7. https://doi.org/10.1038/nature12060

3. World Health Organization (WHO). Global strategy for dengue prevention and control, 2012–2020. Geneva: WHO; 2012. https://www.who.int/publications/i/item/9789241504034

4. Zhang HT, Wang LM, Zhang M, et al. Assessing the global dengue burden: incidence, mortality, and disability-adjusted life years from 1990 to 2021. PLoS Negl Trop Dis 2025; 19(3):e0012932. https://doi.org/10.1371/journal.pntd.0012932

5. Andrioli DC, Busato MA, Lutinski JA. Spatial and temporal distribution of dengue in Brazil, 1990–2017. PLoS One 2020; 15(2):e0228346. https://doi.org/10.1371/journal.pone.0228346

6. Ministério da Saúde (MS). Nota Informativa nº 38/2023 - CGARB/DEDT/SVSA/MS. Brasília: Ministério da Saúde; 2023. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/estudos-e-notas-informativas/2023/nota-informativa-no-38-2023-cgarb-dedt-svsa-ms/view

7. Ministério da Saúde (MS). Diretrizes Nacionais para Prevenção e Controle das Arboviroses Urbanas: Vigilância Entomológica e Controle Vetorial. Brasília: Ministério da Saúde; 2025. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/dengue/diretrizes-nacionais-para-prevencao-e-controle-das-arboviroses-urbanas-vigilancia-entomologica-e-controle-vetorial.pdf/view

8. Rocha MIF, Maranhão TA, Frota MMC, et al. Mortalidade por doenças tropicais negligenciadas no Brasil no século XXI: análise de tendências espaciais e temporais e fatores associados. Rev Panam Salud Publica 2023; 47:e146. https://doi.org/10.26633/RPSP.2023.146

9. Instituto de Pesquisa Econômica Aplicada (IPEA). Atlas da Vulnerabilidade Social nos Municípios Brasileiros. Brasília: IPEA; 2015. https://repositorio.ipea.gov.br/entities/book/7c139f01-9ac7-48fa-8159-ec16018fa98c

10. Malavige GN, Jeewandara C, Ogg GS. Dengue and Covid-19: two sides of the same coin. J Biomed Sci 2022; 29(1). https://doi.org/10.1186/s12929-022-00833-y

11. To KKW, Sridhar S, Chiu KHY, et al. Lessons learned one year after SARS-CoV-2 emergence leading to Covid-19 pandemic. Emerg Microbes Infect 2021; 10(1):507–35. https://doi.org/10.1080/22221751.2021.1898291

12. Veljković M, Pavlović DR, Stojanović NM, et al. Behavioral and dietary habits that could influence both Covid-19 and non-communicable disease prevention. Medicina (Kaunas) 2022; 58(11):1686. https://doi.org/10.3390/medicina58111686

13. Sheng ZY, Li M, Yang R, et al. Covid-19 prevention measures reduce dengue spread in Yunnan Province, China. Emerg Microbes Infect 2021; 11(1):240–9. https://doi.org/10.1080/22221751.2021.2022438

14. Ministério da Saúde (MS). Indicadores Básicos para a Saúde no Brasil: Conceitos e Aplicações [Internet]. Brasília: DATASUS; 2012 [citado 2025 out 1]. Disponível em: http://tabnet.datasus.gov.br/tabdata/livroidb/2ed/indicadores.pdf

15. Brasil. Conselho Nacional de Saúde (CNS). Resolução nº 674, de 06 de maio de 2022: dispensa de apreciação ética para pesquisas com dados públicos, secundários e sem identificação individual. Brasília: CNS; 2022. https://www.gov.br/conselho-nacional-de-saude/pt-br/atos-normativos/resolucoes/2022/resolucao-no-674.pdf/view

16. Teixeira MG, Siqueira JB, Ferreira GLC, et al. Epidemiological trends of dengue disease in Brazil (2000–2010): a systematic literature review and analysis. PLoS Negl Trop Dis 2013; 7(12):e2520. https://doi.org/10.1371/journal.pntd.0002520

17. Ministério da Saúde (MS). Boletim Epidemiológico Vol. 54 nº 1. Brasília: Ministério da Saúde; 2023. https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/boletins/epidemiologicos/edicoes/2023/boletim-epidemiologico-volume-54-no-01/@@download/file/Boletim_epidemiologico_SVS_1_v2.pdf

18. Pinto MS, Ponte CHF, Toledo LFES, et al. Subnotificação de doenças sazonais na pandemia. Braz J Health Rev 2023; 6(5):20971–8. https://doi.org/10.34119/bjhrv6n5-127

19. Leandro CS, Barros FB, Cândido EL, Azevedo FR. Redução da incidência de dengue no Brasil em 2020: controle ou subnotificação de casos por Covid-19? Res Soc Dev 2020; 9(11):e76891110442. https://doi.org/10.33448/rsd-v9i11.10442

Published

2026-08-14

Issue

Section

ORIGINAL ARTICLE

How to Cite

Amaral, M. H., Toledo , G. X., Wingester, E. L. C., Felício, A. C. V., & Brasil, H. A. (2026). Dengue mortality and social vulnerability in Brazilian macro-regions: an ecological study from 2019 to 2023. Revista De Epidemiologia E Controle De Infecção, 16. https://doi.org/10.17058/reci.v16i.20656