Impact of Covid-19 on the profile of mycoses reported in a public hospital in Paraíba, Brazil
DOI:
https://doi.org/10.17058/reci.v15i4.20217Keywords:
Infecções Fúngicas, Co-infecção, Unidade de Terapia Intensiva, Infecção Relacionada à Assistência à SaúdeAbstract
Background and Objectives: Covid-19 can lead to critical immunological conditions, requiring hospitalization in intensive care units. The risk of fungal co-infections increases in these patients, especially if they are on mechanical ventilation, using invasive devices and/or broad-spectrum antibiotics. Secondary fungal infections can worsen the symptoms of the disease, make prognosis and treatment more difficult, and increase mortality and hospital stay rates. Thus, the objective of the present study was to evaluate the influence of the Covid-19 pandemic on the distribution of fungal infections in patients admitted to a university hospital in Paraíba during the period from 2020 to 2022. Methods: A total of 456 medical records from the period between March 2020 and July 2022 sent to the Mycology department with suspected fungal infection were analyzed. Results: Of the medical records evaluated, 120 presented infection by some fungus. Only 17 medical records came from the Covid ICU and 14 of them were positive for some mycosis. The Candidagenus stood out as the most prevalent. It was identified in more than 90% of patients evaluated in the general group and in 85.7% of patients admitted to the Covid ICU. Aspergillus spp., Rhizopus spp. and Mucor spp. were also reported to a lesser extent. Conclusion: The profile of hospital fungal infections was impacted by the pandemic, since a high percentage of Covid ICU patients affected by mycoses was observed in comparison to patients in other departments.
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1. Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020;76:71-6. doi:10.1016/j.ijsu.2020.02.034
2. World Health Organization (WHO) [Internet]. Coronavirus. Disponível em: https://www.who.int/health-topics/coronavirus#tab=tab_1
3. Universidade Aberta do Sistema Único de Saúde (UNA-SUS) [Internet]. Organização Mundial de Saúde declara pandemia do novo Coronavírus; 2020 Mar 11. Disponível em: https://www.unasus.gov.br/noticia/organizacao-mundial-de-saude-declara-pandemia-de-coronavirus
4. Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 2020;38(1):1-9. doi:10.12932/ap-200220-0772
5. Neufeld PM. A COVID-19 e o diagnóstico da aspergilose pulmonar invasiva. Rev Bras Anal Clin. 2020;52(2):173-85. doi:10.0.85.117/2448-3877.20200019
6. Song G, Liang G, Liu W. Fungal co-infections associated with global COVID-19 pandemic: A clinical and diagnostic perspective from China. Mycopathologia. 2020;185(4):599-606. doi:10.1007/s11046-020-00462-9
7. Pemán J, Ruiz-Gaitán A, García-Vidal C, Salavert M, Ramírez P, Puchades F, et al. Fungal co-infection in COVID-19 patients: Should we be concerned? Rev Iberoam Micol. 2020;37(2):41-6. doi:10.1016/j.riam.2020.07.001
8. Agência Nacional de Vigilância Sanitária (ANVISA) [Internet]. Nota Técnica GVIMS/GGTES/ANVISA nº 04/2021 - Infecções Fúngicas; 2021 Jun 14. Disponível em: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/notas-tecnicas/notas-tecnicas-vigentes/nota-tecnica-04-2021-infeccoes-fungicas-e-covid19.pdf/view
9. World Health Organization (WHO) [Internet]. WHO releases first-ever list of health-threatening fungi; 2022 Out 25. Disponível em: https://www.who.int/news/item/25-10-2022-who-releases-first-ever-list-of-health-threatening-fungi
10. David CMM. Infecção em UTI. Medicina (Ribeirão Preto). 1998;31(3):337-48. doi:10.11606/issn.2176-7262.v31i3p337-348
11. Leiser JJ, Tognim MCB, Bedendo J. Infecções hospitalares em um centro de terapia intensiva de um hospital de ensino no norte do Paraná. Cienc Cuid Saude. 2007;6(2):181-6. doi:10.4025/ciencuidsaude.v6i2.4149
12. Svedese VM, Macedo ES, Leão IF, Diniz MC. COVID-19 e doenças fúngicas invasivas. Saúde e Meio Ambient: Rev Interdisciplin. 2022;11:25-42. doi:10.24302/sma.v11.3865
13. Colombo AL, Guimarães T. Epidemiologia das infecções hematogênicas por Candida spp. Rev Soc Bras Med Trop. 2003;36(5):599-607. doi:10.1590/S0037-86822003000500010
14. Epelbaum O, Chasan R. Candidemia in the intensive care unit. Clin Chest Med. 2017;38(3):493-509. doi:10.1016/j.ccm.2017.04.010
15. Murray PR, Rosenthal KS, Pfaller MA. Microbiologia médica. 8a ed. Rio de Janeiro: Elsevier; 2017. 848 p.
16. Vieira FMRM. Candida não-albicans como patogénicos emergentes [dissertação de mestrado]. Lisboa: Instituto Superior de Ciências da Saúde Egas Moniz; 2016. Disponível em: http://hdl.handle.net/10400.26/17657
17. Sabino R, Veríssimo C, Brandão J, Alves C, Parada H, Rosado L, et al. Epidemiology of candidemia in oncology patients: A 6-year survey in a Portuguese central hospital. Med Mycol. 2010;48(2):346-54. doi:10.1080/13693780903161216
18. Agência Nacional de Vigilância Sanitária (ANVISA) [Internet]. Alerta de risco GVIMS/GGTES/ANVISA nº 01/2022; 2022 Nov 1. Disponível em: https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosdesaude/comunicados-de-risco-1/alerta-de-risco-gvims-ggtes-anvisa-no-01-2022/view
19. Freitas MC. Infecções fúngicas associadas a COVID-19. Boletim Microvita. 2022. doi:10.0.38.43/bmicrov.v0i3.47758
20. Martins AC, Psaltikidis EM, de Lima TC, Fagnani R, Schreiber AZ, Conterno LO, et al. COVID-19 and invasive fungal coinfections: A case series at a Brazilian referral hospital. J Mycol Med. 2021;31(4):101175. doi:10.1016/j.mycmed.2021.101175
21. Mahalaxmi I, Jayaramayya K, Venkatesan D, et al. Mucormycosis: An opportunistic pathogen during COVID-19. Environ Res. 2021;201:111643. doi:10.1016/j.envres.2021.111643
22. Ministério da Saúde (Brasil) [Internet]. Situação epidemiológica; 2022 Nov 3. Disponível em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/m/mucormicose/situacao-epidemiologica
23. de Almeida JN Jr, Moreno L, Francisco EC, Marques GN, Mendes AV, Barberino MG, et al. Trichosporon asahii superinfections in critically ill COVID-19 patients overexposed to antimicrobials and corticosteroids. Mycoses. 2021;64(8):817-22. doi:10.1111/myc.13333
24. Bustamante KBR. COVID-19 e coinfecções fúngicas [trabalho de conclusão de curso de graduação]. São Paulo: UNIFESP; 2022. Disponível em: https://repositorio.unifesp.br/xmlui/handle/11600/63364
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