Effectiveness of interventions in robust and pre-frail older adults: systematic review

Authors

DOI:

https://doi.org/10.17058/00c7bt30

Keywords:

Frailty, Therapeutic Interventions, Aged, Pre-fragile

Abstract

Objective: To analyze the effectiveness of interventions to prevent frailty in robust and pre-frail elderly people. Method: A systematic review was carried out, according to the methodology proposed by the Joanna Briggs Institute (JBI), with studies published between 2018 and 2023, with the keywords “prevention”, “frailty”, “older people”, “intervention”, and related terms. Studies were included that described interventions to prevent frailty in the elderly, robust and pre-frail, aged 60 years or older. To evaluate the methodological quality of Randomized Clinical Trials (RCT) articles, the PEDro Scale was used. Results: 15 eligible studies were identified. Among them, eight RCTs demonstrated high methodological rigor and high quality, while 3 NRSs achieved a high-quality rating. The interventions analyzed included physical exercise programs, nutritional strategies, cognitive stimulation, and combined approaches. It was observed that multidimensional and multicomponent interventions, by integrating physical, cognitive, and nutritional components, demonstrated greater potential for effectiveness, resulting in improved functional parameters, reduced risk of frailty, and promoted autonomy in older adults. Most studies reported positive outcomes, although methodological heterogeneity and context variability limited direct comparisons. Conclusion: The findings suggest that multicomponent and integrated interventions represent promising strategies for preventing frailty in robust and pre-frail older adults. Nevertheless, additional studies focusing on individualized interventions are needed to consolidate evidence and guide implementation in public policies and care practices.

Downloads

Download data is not yet available.

Author Biographies

  • Mariana Porto, Universidade Federal de São Carlos

    Bacharelado em Educação Física pela Universidade Estadual Paulista, Júlio de Mesquita;
    Pós Graduação em Fisiologia do Exercício pela Universidade Federal de São Carlos;
    Mestrado em Gerontologia pela Universidade Federal de São Carlos, SP, Brasil.

  • Andréa Rodrigues de Amorim Molina, Universidade Federal de São Carlos

    Bacharelado em Educação Física pela Universidade Estadual Paulista, Rio Claro, SP, Brasil
    Mestre em Educação - Ensino Superior no Programa de Pós-Graduação em Educação na Pontifícia Universidade Católica de Campinas, SP, Brasil
    Doutoranda em Fisioterapia pela Universidade Federal de São Carlos, SP, Brasil.

  • Andressa Crystine da Silva Sobrinho , Universidade de São Paulo

    Bacharelado  em Educação física pela Universidadede São Paulo;
    Mestrado e doutoranda em Ciências da Saúde, clínica médica, pela Universidadede São Paulo.

  • Luana K. Ferreira, Universidade Federal de Juiz de Fora

    Bacharelado em Nutrição pela Universidade Federal de Juiz de Fora;
    Mestrado e doutorado em Psicologia pela Universidade Federal de Juiz de Fora;
    Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.

  • Letícia Fernanda Belo , Universidade de São Paulo - São Carlos

    Bacharelado em Gerontologia pela Universidade Federal de São Carlos;
    Mestranda do Programa de Pós-Graduação Interunidades em Bioengenharia pela Universidade de São Paulo.

  • Grace Angélica de Oliveira Gomes , Universidade Federal de São Carlos

    Bacharelado em Educação Física pela Universidade Federal de Juíz de Fora
    Mestre em Gerontologia pela Universidade Estadual de Campinas
    Doutora em Ciências da Motricidade pela Universidade Estadual Paulista Júlio Mesquita
    Pós doutorado pela University of Queensland.

References

1. Rabelo MA, Sebba M, Galhardo VAC, Mello JLC. Fragilidade e qualidade de vida em idosos. Research, Society and Development. 2023 Mar 19;12(3): e26712340738-e26712340738. doi: http://dx.doi.org/10.33448/rsd-v12i3.40738.

2. Rockwood K, Howlett SE, MacKnight C, et al. Prevalence, Attributes, and Outcomes of Fitness and Frailty in Community-Dwelling Older Adults: Report from the Canadian Study of Health and Aging. The Journals of Gerontology: Series A. 2004 Dec;59(12):1310–7.

3. Barbosa GC, Caparrol AJS, Melo BRS et al. Fatores correlacionados à fragilidade de idosos em atenção ambulatorial: diferença entre grupos etários. Escola Anna Nery 2023, 26, p. e20210408. doi: https://doi.org/10.1590/2177-9465-EAN-2021-0408pt.

4. Junior EPP, Marques CG, Silva AVS, et al. Prevalência e fatores associados ao fenótipo da fragilidade em idosos brasileiros: uma revisão de literatura. Revista Kairós: Gerontologia [Internet]. 2015 Sep 30 [cited 2025 Jan 28];18(3):353–66. doi: https://doi.org/10.23925/2176-901X.2015v18i3p353-366.

5. Silva SLAS, Brito GEG, Ygnatios NTM, et al. [Differences between men and women in the prevalence of frailty and associated factors among older adults: evidence from ELSI-Brazil]. Cad Saúde Pública. 2024 Jan 1;40(3):e00144923–3. doi: https://doi.org/10.1590/0102-311xpt144923.

6. Maia LC, Moraes EN de, Costa S de M, Caldeira AP. Fragilidade em idosos assistidos por equipes da atenção primária. Ciênc. Saúde Colet. 2020 Dec;25(12):5041–50. doi: https://doi.org/10.1590/1413-812320202512.04962019.

7. Grden CRB, Barreto MFC, de Sousa JAV, et al. Association between physical frailty and cognitive scores in older adults. Rev Rene. 2015 Jun 28;16(3). doi: https://doi.org/10.15253/2175-6783.2015000300012.

8. Faria A, Martins MMFPS, Laredo-Aguilera JA, et al. Fragilidade em pessoas idosas residentes no domicílio inscritas numa unidade de saúde do norte de Portugal. Revista Portuguesa de Enfermagem de Reabilitação. 2021 Jun 30;4(1):6–14. doi: https://doi.org/10.33194/rper.2021.v4.n1.46.

9. De Sousa JCS, De Castro TRO, Rodrigues JA, et al. Síndrome da fragilidade em idosos: prevalência, critérios para identificação e fatores associados. Enfermagem Brasil. 2021 Aug 12;20(3):429–47. doi: https://doi.org/10.33233/eb.v20i3.4339.

10. Costa LGO, Cruz AO, Noronha, DO, et al. Percepção do idoso frágil, do cuidador e do fisioterapeuta sobre a funcionalidade após tratamento fisioterapêutico ambulatorial. Revista Brasileira de Ciência e Movimento [Internet]. 2020;28(2). doi: https://doi.org/10.31501/rbcm.v28i2.10596.

11. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an Updated Guideline for Reporting Systematic Reviews. British Medical Journal [Internet]. 2021 Mar 29;372(71). doi: https://doi.org/10.1136/bmj.n71.

12. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement. PLoS Medicine. 2009 Jul 21;6(7). doi: https://doi.org/10.1371/journal.pmed.1000097.

13. Cumpston MS, McKenzie JE, Thomas J, Brennan SE. The use of “PICO for synthesis” and methods for synthesis without meta-analysis: protocol for a survey of current practice in systematic reviews of health interventions. F1000Res. [Internet]. 2021 Jan 29;9(2):678. doi: https://doi.org/10.12688/f1000research.24469.2.

14. Aromataris E, Lockwood C, et al. JBI Manual for Evidence Synthesis. JBI eBooks. JBI; 2024.

15. BITENCOURT, Fernando Valentim et al. Análise da qualidade metodológica de estudos observacionais (coorte e caso-controle) com a ferramenta Newcastle-Ottawa Scale (NOS). In: Risco de viés em revisões sistemáticas: guia prático. 2021.

16. Fhon JRS, Diniz MA, Leonardo KC, et al. Síndrome de fragilidade relacionada à incapacidade funcional no idoso. Acta Paulista de Enfermagem. 2012 Jul 31;25(4):589–94. doi: https://doi.org/10.1590/S0103-21002012005000016.

17. Almohaisen N, Gittins M, Todd C, et al. Prevalence of Undernutrition, Frailty and Sarcopenia in Community-Dwelling People Aged 50 Years and Above: Systematic Review and Meta-Analysis. Nutrients. 2022 Apr 7;14(8):1537. doi: https://doi.org/10.3390/nu14081537.

18. Kaunitz AM, Pinkerton JV, Manson JE. Hormone therapy and sarcopenia: implications for the prevention of frailty as women age. Menopause. 2020 Mar;27(5):1. doi: https://doi.org/10.1097/gme.0000000000001541.

19. Ekram ARMS, Woods RL, Britt C, et al. The Association Between Frailty and All-Cause Mortality in Community-Dwelling Older Individuals: An Umbrella Review. J Frailty Aging. 2021; 10:1–7. doi: https://doi.org/10.14283/jfa.2021.20.

20. Scholz U, König C, Eicher S, Martin M. Stabilisation of health as the centre point of a health psychology of ageing. Psychol Health. 2015 Jan 26;30(6):732–49. doi: https://doi.org/10.1080/08870446.2014.991733.

21. Dantas EHM, Santos CAS, et al. Aspectos biopsicossociais do envelhecimento. São João del-Rei: Universidade Federal de São João del-Rei; 2017.

22. Chalise HN, Nath H, Prithvi N, et al. Healthy Ageing: A Basic Concept. Asian Journal of Population Sciences. 2023 Jan 10; 2:124–8. doi: http://dx.doi.org/10.3126/ajps.v2i1.51096.

23. Buto MS de S, de Oliveira MPB, Carvalho C, et al. Effect of complementary therapies on functional capacity and quality of life among prefrail and frail older adults: A systematic review of randomized controlled trials. Arch Gerontol Geriatr. 2020 Nov; 91:104236. doi: https://doi.org/10.1016/j.archger.2020.104236.

24. Moseley AM, Rahman P, Wells GA, et al. Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions. Hübscher M, editor. PLOS ONE. 2019 Sep 19;14(9): e0222770. doi: https://doi.org/10.1371/journal.pone.0222770.

25. Shiwa SR, Costa LOP, Moser AD de L, et al. PEDro: a base de dados de evidências em fisioterapia. Fisioterapia em Movimento [Internet]. 2011 Sep;24(3):523–33. doi: https://doi.org/10.1590/S0103-51502011000300017.

26. Filipec M, Kuzmić A, Degač NZ. Assessing the quality of research outputs in physiotherapy. In: PUBMET2022 The 9th Conference on Scholarly Communication in the Context of Open Science: book of abstracts. Zadar: Sveučilište u Zadru; 2022. p. 56-7.

27. Santamaría‐Ulloa C, Lehning AJ, Cortés-Ortiz MV, et al. Frailty as a predictor of mortality: a comparative cohort study of older adults in Costa Rica and the United States. BMC Public Health. 2023 Oct 10;23(1). doi: https://doi.org/10.1186/s12889-023-16900-4.

28. Soytaş RB, Levinoff EJ, et al. Predictive Strategies to Reduce the Risk of Rehospitalization with a Focus on Frail Older Adults: A Narrative Review. Epidemiologia. 2023 Oct 8;4(4):382–407. doi: https://doi.org/10.3390/epidemiologia4040035.

29. Melo RC, Cipolli GC, Buarque GLA, et al. Prevalence of frailty in Brazilian older adults: a systematic review and meta-analysis. J Nutr Health Aging. 2020;24(7):708-716. Doi: 10.1007/s12603-020-1398-0.

30. Silva SLA, Mattos IE, Azevedo e Silva G, et al. Diferenças entre homens e mulheres na prevalência da fragilidade e fatores associados entre adultos mais velhos: evidências do ELSI-Brasil. Cad Saude Publica. 2024;40. doi: 10.1590/0102-311XPT144923.

31. Gwyther H, Bobrowicz-Campos E, Apóstolo JLA, et al. A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty. Health Psychol Rev. 2018 Jun 25;12(4):382–404. doi: https://doi.org/10.1080/17437199.2018.1488601.

32. Negm AM, Kennedy CC, Thabane L, et al. Management of Frailty: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials. J Am Med Dir Assoc [Internet]. 2019 Oct ;20(10):1190–8. doi: https://doi.org/10.1016/j.jamda.2019.08.009.

33. Travers J, Romero-Ortuno R, Bailey J, Cooney MT. Delaying and reversing frailty: a systematic review of primary care interventions. Br J Gen Pract [Internet]. 2018 Dec 3;69(678):e61–9. doi: https://doi.org/10.3399/bjgp18x700241.

34. de Mello BH, Lenardt MH, Moraes DC, et al. Alteração cognitiva e fragilidade física em idosos da atenção secundária à saúde. Rev Esc Enferm USP [Internet]. 2021 Apr 16;55:e03687. doi: https://doi.org/10.1590/S1980-220X2019029803687

35. O’Caoimh R, Galluzzo L, Rodríguez-Laso A, et al. Prevalence of frailty at population level in European ADVANTAGE Joint Action Member States: a systematic review and meta-analysis. Annali dell’Istituto Superiore di Sanità [Internet]. 2014;54(3):226–38. doi: https://doi.org/10.4415/ann_18_03_10.

36. Hoogendijk EO, Dent E. Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review. Ann Geriatr Med Res. 2022 Dec 31;26(4):289–95. doi: https://doi.org/10.4235/agmr.22.0148.

37. Mohandas A, Reifsnyder J, Jacobs M, Fox T. Current and Future Directions in Frailty Research. Popul Health Manag. 2011 Dec;14(6):277–83. doi: https://doi.org/10.1089/pop.2010.0066.

38. Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. The Lancet [Internet]. 2019 Oct;394(10206):1365–75. doi: https://doi.org/10.1016/S0140-6736(19)31786-6.

39. Cano-Escalera G, Graña M, Irazusta J, et al. Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital. J Clin Med. 2023 Apr 24;12(9):3103–3. doi: https://doi.org/10.3390/jcm12093103.

40. Huguet LG, Kostov B, Navarro González M, et al. Long-Term Effects on Preventing Frailty and Health Care Costs Associated with a Multifactorial Intervention in the Elderly: Three-Year Follow-Up Data from the Pre-Frail 80 Study. Gerontology. 2022 Feb 4;68:1–11. doi: https://doi.org/10.1159/000521497

Published

2026-05-01

Issue

Section

ARTIGO DE REVISÃO

How to Cite

Schwenger, L. L., Porto, M., Rodrigues de Amorim Molina, A. ., Crystine da Silva Sobrinho , A. ., K. Ferreira, L., Fernanda Belo , L. ., & Angélica de Oliveira Gomes , G. . (2026). Effectiveness of interventions in robust and pre-frail older adults: systematic review. Interdisciplinary Journal of Health Promotion, 9. https://doi.org/10.17058/00c7bt30