Covid-19 develops late oxidative damage in those admitted to the Intensive Care Unit and presents low recovery rate when compared with individuals without the disease

Authors

• Pietra de Vargas Minuzzi Hospital Santa Cruz/Residente https://orcid.org/0000-0001-9649-345X
• Gênifer Erminda Schreiner Universidade Federal do Pampa https://orcid.org/0000-0002-0203-3944
• Laura Smolski dos Santos Universidade Federal do Pampa https://orcid.org/0000-0001-8858-9654
• Elizandra Gomes Schmitt Universidade Federal do Pampa https://orcid.org/0009-0007-9813-5542
• Luana Tamires Maders Universidade Federal do Pampa https://orcid.org/0009-0008-2948-7023
• Marta Fioravanti Carpes Universidade Federal do Pampa https://orcid.org/0000-0002-3879-0621
• Rafael Tamborena Malheiros Hospital Santa Casa de Uruguaiana https://orcid.org/0000-0002-6163-3122
• Vanusa Manfredini Universidade Federal do Pampa https://orcid.org/0000-0002-9622-7861

DOI:

https://doi.org/10.17058/rips.v8i2.19291

Keywords:

SARS-CoV-2, Oxidative Stress, Intensive care therapy, Hospitalization

Abstract

Objective: compare the oxidative damage and antioxidant defense of individuals with and without Covid-19 admitted to the ICU and monitor the hospitalization process until presenting a clinical outcome of hospital discharge or death. Method: the study consisted of 95 individuals (42 in the ICU Covid and 53 in the adult ICU), which through blood samples and using classical methodologies it was possible to analyze the levels of total glutathione (GSH), Total Antioxidant Status (TAS), vitamin C and D, Lactate Dehydrogenase (LDH) oxidative damage in biomolecules (lipids, proteins and DNA).. In addition, mortality prediction was accompanied by Acute Physiology and Chronic Health disease Classification System II (APACHE II), Simplified Acute Physiology Score (SAPS II) and Sequential Organ Failure Assessment (SOFA) scores. Results: through the data obtained, there is a greater damage to protein in the last evaluation of the adult ICU and an increase in DNA damage in individuals hospitalized in the adult ICU in both the first and last evaluation. In addition, there was a reduction of vitamin D in the ICU Covid in the first evaluation and an increase in LDH in the last evaluation, and the individuals of the adult ICU showed a significant increase in SAT and GSH in both moments of evaluation. Conclusion: through the above, we believe that the greater severity at the time of admission and greater damage to the protein due to the hospitalization process of individuals admitted to the adult ICU may be related to sepsis and that the increase in the severity and mortality of cases of individuals admitted to the Covid ICU may suggest that this disease leads to late oxidative damage, with a low recovery rate.

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